Substitute Son Heung-min added the third in the 84th minute to ensure a winning start for Spurs to their Group J campaign.
Manager Jose Mourinho rested several regulars, but his side were quickly in command with debutant Carlos Vinicius spurning a headed chance from close range inside the opening 10 minutes.
But the club’s new Brazilian signing from Benfica quickly made up for it by collecting captain Ben Davies’ long pass with a determined run before squaring it perfectly for compatriot Lucas to tuck away the opening goal.
A surging run from Sergio Reguilon led to the second, with Bale trying to find Vinicius with a pass from the right side of the attack that a panicked Andrade turned into his own net.
Bale, back at Spurs on loan from Real Madrid, went off after an hour, still looking short of match fitness, to be replaced by in-form Son, who lifted the energy of the home team.
Son, fellow substitute Dele Alli and Lucas all had decent chances to add to the goal tally before the South Korean claimed the third, tucking the ball away after a sweeping move in the that included a deft headed pass from the impressive Vinicius.