Coronavirus cases are continuing to rise in nine of 10 Greater Manchester boroughs, the latest figures show.
This is well below the national average rate for the whole of England of 396.9.
However, the data shows positive cases are rising in all but one borough, with positive cases rising rapidly in some areas.
Trafford currently has the highest rate of all areas with a rate of 251.5 per 100,000 in the week ending December 26 – an increase of 45 per cent.
The rate in Bury stands at 231.4, meaning it is up 11pc week-on-week.
The transmission rate of the virus has also increased massively in Stockport, Wigan and Tameside.
In Stockport, the rate stands at 227.0 – this has risen by 67pc since the previous week.
The rate in Tameside, now 177.9, has gone up by 33pc; and in Wigan it has increased by 26pc to 194.7.
Transmission rates have also increased in Rochdale, Salford, Manchester and Bolton.
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Oldham is the borough where cases have fallen. The rate there now stands at 170.1, down 8pc on the previous week.
Overall, positive cases have been rising in the region since December 8.
Te number of daily cases being recorded is nowhere near Greater Manchester’s peak in October.
The average rate for cases in the region is expected to increase in the next few days, following a quiet period of testing over the Christmas period.
The latest figures come as the region is set to move into Tier 4 tomorrow – the tightest set of restrictions.
It means that non-essential shops, hairdressers, gyms, leisure and entertainment venues – such as cinemas – must close on top of normal Tier 3 closures.
People will be asked to stay at home where possible – unless there’s a reasonable excuse.
Residents will also be told not to mix with anyone outside of their household or support bubble, with few exceptions.
Mr Hancock said: “Sharply rising cases and the hospitalisations that follow demonstrate the need to act where the virus is spreading.”
The Health Secretary told MPs that the majority of new cases recorded yesterday ‘are believed to be the new variant’.
Mr Hancock added: “Unfortunately, this new variant is now spreading across most of England and cases are doubling fast.
“It is therefore necessary to apply Tier 4 measures to a wider area, including the remaining parts of the south east, as well as large parts of the Midlands, the north west, the north east and the south west.”