So, after a bruising Merseyside derby, how does Jurgen Klopp re-assemble the pieces for Liverpool’s next assignment?
The Premier League champions were left counting the cost of their 237th game against Everton on Saturday, walking away from Goodison Park with little but insult, injury and injustice.
On the latter, Liverpool remain hopeful that his problem is not a serious one following the high lunge that saw Richarlison shown a straight red by referee Michael Oliver.
Liverpool will feel they have some unfinished business in European football given how they exited the Champions League back in March.
After peppering the Atletico Madrid goal with as many as 34 shots in the last game played with fans at Anfield, they somehow walked away with a 3-2 defeat after extra time.
The match, as has been well publicised, perhaps should not have even gone ahead given the influx of fans from Madrid where the COVID-19 crisis stood as the worst in Europe at the time.
Just two days later, the Premier League announced a pause that it would stay on for three months and fans have not been at a top flight match in this country since.
But that gripe is water under the bridge, from a purely sporting perspective, as Liverpool look to regain the title they relinquished on March 11.
The world looks a lot different since that Anfield evening, but the Reds’ resolve to become champions of Europe has not been diluted.
For Klopp, though, there are several problems to solve ahead of the club’s first game with Ajax since 1996.
Despite Alisson Becker’s positive injury update from his manager on Friday, this game in the Dutch capital is likely to come too soon for the Brazilian.
That means Adrian will retain his place behind a back four that will presumably feature Trent Alexander-Arnold and Andy Robertson.
In the centre of defence, Van Dijk’s absence leaves Klopp with little option but to pick Joel Matip and Joe Gomez.
Klopp’s numbers are at their most thin in the centre of defence, given they have just three senior centre-halves on the books.
Fabinho is an option but he is more than likely expected to feature further forward as a defensive midfielder against Erik ten Hag’s men.
Thiago looks set to miss out following his injury in the derby, which could lead to a recall for Gini Wijnaldum alongside captain Jordan Henderson.
Naby Keita is not expected to be ready meaning Wijnaldum, if Thiago is indeed out as expected, will surely be given the nod ahead of James Milner as Alex Oxlade-Chamberlain continues his own recovery.
The in-form Mohamed Salah will start on the right of the front three while his running mate, Sadio Mane, will line up on the opposite flank.
Takumi Minamino and Diogo Jota are viable options for Klopp at the Johan Cruyff Arena, also.
However, given Roberto Firmino’s goals have tended to be away from home for much of the last year or so, the Reds boss might be tempted to stick rather than twist.