As if facing an in-form France wasn’t enough, Ireland will be without hugely experienced half-back duo Johnny Sexton and Conor Murray.
Sexton is out having suffered a blow to the head in last week’s defeat to Wales, while Murray has picked up a hamstring problem in training.
Ulster’s Billy Burns comes in at 10, with Jamison Gibson-Park starting in at scrum-half.
Farrell has made two other changes, recalling back row Rhys Ruddock and lock Iain Henderson in place of the suspended Peter O’Mahony and injured vice-captain James Ryan.
Ireland starting XV to face France: H Keenan, K Earls, G Ringrose, R Henshaw, J Lowe, B Burns, J Gibson-Park; C Healy, R Herring, A Porter, T Beirne, I Henderson (c), R Ruddock, J van der Flier, CJ Staner.
Replacements: R Kelleher, E Byrne, T Furlong, U Dillane, W Connors, C Casey, R Byrne, J Larmour.